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Discussion

The rapid appearance of HIV-1 strains that are resistant to AIDS drugs is due in part to which of the following property of its reverse transcriptase?

  • A.AZT (zidovudine) is too expensive to be taken in effective doses
  • B.The RNase H domain of p66 causes error prone synthesis
  • C.It lacks a proofreading exonuclease
  • D.It has low affinity for the correct dNTP's

Answer: C

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